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First Editions of Adam Smith's Wealth of Nations, (1776) Essays on Philosophical Subjects (1795) and most important The Theory of Moral Sentiments (1759)
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Only copy in private hands of third Dunlap printing of the Declaration of Independence. (1777)
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Mary Wollstonecraft's
A Vindication of the Rights of Woman (1792) First Edition and Letters (1796)
One of the few people to whom Thomas Paine would listen.
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Thomas Hobbes' De Cive (1651) and Leviathan. (1651)
Both first Editions.
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Desiderius Erasmus' The Praise of Folly (1549)

Early English Edition

Erasmus was the last guy to know everything.

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Alexis de Tocqueville's Democracy in America
One of the most important texts in political literature.

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John Locke's Two Treatises of Government (1694)
and An Essay Concerning Humane Understanding (1690) First Edition

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First Pamphlet printing of the United States Constitution and reprint. 1787

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Aristotle's Opera (1496).
An incunable

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Aristotle's Politiques, or Discourses of Government (1598)
and Plato's Republic (1763)
1st English Translation

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Thomas Aquinas' Summa Thealogica (1475)
One of three known in the world. An incunable.